Precision & Integrative Oncology for Thyroid Cancer | Advanced Treatment Strategies

Precision Oncology
in Thyroid Cancer

Precision Oncology in Thyroid Cancer

Introduction

Precision Oncology focuses on understanding the genomic changes that lead to the development of neoplasia in thyroid tissue. This approach aids in confirming the diagnosis and formulating a systemic treatment plan, especially for advanced and undifferentiated types of thyroid cancer.

Role in Diagnosis

Cytology samples, along with microscopic evaluation, can undergo genetic analysis using Next Gen Sequencing (NGS).
Detection of high-risk genes indicates a higher likelihood of malignancy.
Based on this, a decision can be made to proceed with a total thyroidectomy, eliminating the need for an initial hemithyroidectomy followed by a completion thyroidectomy.

Treatment Planning for Advanced Stages & Undifferentiated Histology

Traditional chemotherapy often proves ineffective against thyroid cancer.

For advanced or recurrent cases, Precision Oncology methods are employed to determine the most suitable chemotherapy, targeted therapy, immunotherapy drugs, and even explore nutraceutical options.

This ensures a tailored treatment plan that best addresses each patient’s unique condition.

Precision Oncology Methods and Our Lab Partners

NGS on Cytology Specimens:

Helps distinguish neoplasia from benign adenoma.
Assists in deciding the surgical approach: Hemi vs. Total Thyroidectomy.
Lab Partners: 4 Basecare and Medgenome.

Systemic Treatment Planning:

Tumor Viability Assays: Circulating Tumor Cells (CTCs) are identified through a liquid biopsy. These cells are then grown in a lab to test the efficacy of various treatments.
Drugs are selected based on their ability to inhibit tumor growth in vitro.
Important Note: In vitro results may not always replicate in vivo.
Lab Partners: RGCC Labs (located in Greece, Switzerland, and Germany).

Transcriptomic Analysis:

Evaluates the variations in mRNA expressions.
Provides insights into the pathways that need addressing.
Used in prescribing natural supplements to enhance cancer control.

By understanding and leveraging the power of Precision Oncology, we aim to provide the most effective and personalized treatment options for patients with thyroid cancer.

Key Genes to Target Thyroid Cancer

At The Thyroid Cancer Clinic, we prioritize understanding the genetic underpinnings of thyroid cancer to provide the most effective and targeted treatments for our patients. Our dedicated team of experts utilizes advanced genomic testing to identify mutations in the following key genes associated with thyroid cancer:

BRAF – Predominantly found in papillary thyroid carcinomas, especially the BRAF V600E mutation.
RET/PTC – Rearrangements in this gene are a hallmark of papillary thyroid cancer.
KRAS – Found in various cancers, including thyroid cancer.
NRAS – Another member of the RAS family, mutations in NRAS are also indicative of thyroid cancer.
NTRK1 – Rearrangements in NTRK1 are sometimes associated with papillary thyroid carcinomas.
TP53 – Mutations in TP53 are linked with aggressive thyroid tumors, especially anaplastic thyroid cancer.
PTEN – Mutations can lead to Cowden syndrome, increasing the risk of follicular thyroid cancer.
TERT – Promoter mutations in TERT are associated with more aggressive forms of thyroid cancer.
ALK – Some thyroid cancers have identified rearrangements in the ALK gene.
MET – Associated with various cancers, including thyroid cancer.
PIK3CA – Found in a variety of cancers, this gene’s mutations are also present in thyroid cancer.
NF1 – Mutations can lead to neurofibromatosis type 1, associated with an increased risk of certain thyroid cancers.
FGFR2 – Identified in various cancers, including thyroid cancer.
FGFR3 – While primarily associated with bladder and skin cancers, mutations in FGFR3 have also been identified in thyroid cancer.

The Thyroid Cancer Clinic is at the forefront of personalized medicine. By identifying and understanding these genes, we can tailor treatments to individual patient needs. Our comprehensive approach includes not only genomic testing but also targeted therapies, ensuring the best possible outcomes for our patients. We are committed to providing cutting-edge care, research, and support to all our patients, ensuring they receive the most advanced treatments available.

Precision Oncology at The Thyroid Cancer Clinic

Integrative Oncology through Precision Oncology

At The Thyroid Cancer Clinic, we believe in a holistic approach to treating thyroid cancer. Our precision oncology initiative is a testament to this belief, ensuring that every patient receives a treatment plan tailored to their unique genetic profile. Here’s how we achieve this:

Gene Mutation Analysis: Before anything else, we delve deep into the genetic makeup of the tumor. By identifying all gene mutations, we gain a comprehensive understanding of the cancer’s origins and behavior.

RNA Overexpression Analysis: Beyond just genes, we analyze RNA overexpressions. This gives us insights into which genes are being overexpressed, leading to aggressive tumor behavior.

Beyond Conventional Therapies: While conventional treatments like chemotherapy, targeted therapy, and immunotherapy play a crucial role, we believe in going beyond. Our approach is integrative, combining the best of conventional medicine with advanced genomic insights.

Nutraceutical Intervention: One of our pioneering approaches is the use of nutraceuticals. By identifying the right nutraceuticals, we can block the protein overexpression caused by specific gene mutations. This not only halts tumor growth but does so using natural compounds, reducing side effects.

Personalized Treatment Plans: Every patient is unique, and so is their cancer. By integrating all the above points, we craft a treatment plan that is tailored to the individual. This ensures the highest chances of success and the best possible quality of life during and after treatment.

At The Thyroid Cancer Clinic, we are redefining the future of thyroid cancer treatment. Through precision oncology, we are ensuring that every patient gets the care they truly deserve.